doxepin and ganaxolone both increase sedation. Cyclic antidepressants aren't considered addictive. doxepin, dobutamine. Use Caution/Monitor. Minor/Significance Unknown. Clinical Drug Interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. May cause increase or decrease in blood pressure. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and dronedarone both increase QTc interval. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin increases and lisdexamfetamine decreases sedation. Monitor Closely (1)doxepin increases and phenylephrine PO decreases sedation. doxepin and lofepramine both decrease cholinergic effects/transmission. Serious - Use Alternative (2)doxepin and lumefantrine both increase QTc interval. Lorazepam and doxepin both increase sedation. . Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)cyproheptadine and doxepin both increase sedation. Risk of arrhythmias or hypotension. Use Caution/Monitor. Contraindicated. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Additive anticholinergic effects. Other (see comment). Serious - Use Alternative (1)doxepin and lenvatinib both increase QTc interval. Use Caution/Monitor. risperidone and doxepin both increase sedation. doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Minor/Significance Unknown. Monitor Closely (1)doxepin and marijuana both increase sedation. Use Caution/Monitor. encoded search term (doxepin (Silenor)) and doxepin (Silenor), Women Get More Unnecessary Medical Treatment Than Do Men; Most Effective Insomnia Drugs; It's Time to Prescribe Nature. Avoid or Use Alternate Drug. pentobarbital and doxepin both increase sedation. Modify Therapy/Monitor Closely. Monitor Closely (1)droperidol and doxepin both increase sedation. mitotane decreases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin and vemurafenib both increase QTc interval. Use Caution/Monitor. doxepin, norepinephrine. Minor/Significance Unknown. Serious - Use Alternative (1)nefazodone and doxepin both increase serotonin levels. Use Caution/Monitor. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. May give qHS to decrease daytime sedation, To minimize potential for next day drowsiness, do not take within 3 hr of a meal (AUC increased by 41% and Cmax by 15% when taken with high fat meal), calcium/magnesium/potassium/sodium oxybates, elvitegravir/cobicistat/emtricitabine/tenofovir DF, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol, Neonates exposed to TCAs, including doxepin, late in third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding; such complications can arise immediately upon delivery, Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hyperreflexia, tremor, jitteriness, irritability and constant crying. Use Caution/Monitor. Use Caution/Monitor.doxepin and protriptyline both increase sedation. A brief history of the development of antidepressant drugs: from monoamines to glutamate. Use Caution/Monitor. fexinidazole will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. information highlighted below and resubmit the form. Minor (1)zolpidem, doxepin. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Antidepressants: Selecting one that's right for you. Minor/Significance Unknown. Canada residents can call a provincial poison control center. Minor/Significance Unknown. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Avoid or Use Alternate Drug. Monitor Closely (2)cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. doxepin increases and epinephrine decreases sedation. Avoid or Use Alternate Drug. abobotulinumtoxinA increases effects of doxepin by pharmacodynamic synergism. doxepin decreases effects of clonidine by Other (see comment). clomipramine and doxepin both increase sedation. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)chlordiazepoxide and doxepin both increase sedation. Serious - Use Alternative (1)doxepin and osimertinib both increase QTc interval. Avoid or Use Alternate Drug. Comment: Amifampridine can cause seizures. Modify Therapy/Monitor Closely. Coadministration may increase risk for adverse effects of CYP3A4 substrates. chloral hydrate and doxepin both increase sedation. promazine and doxepin both increase QTc interval. dexchlorpheniramine and doxepin both increase sedation. Individual plans may vary Contraindicated. Avoid or Use Alternate Drug. Other (see comment). doxepin increases toxicity of oliceridine by Other (see comment). Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. rivastigmine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug.doxepin and imipramine both increase serotonin levels. Before fluvoxamine and doxepin both increase serotonin levels. Monitor Closely (1)valerian and doxepin both increase sedation. doxepin and bedaquiline both increase QTc interval. Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Serious - Use Alternative (1)givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. difenoxin hcl and doxepin both increase sedation. Monitor Closely (1)doxepin and alfuzosin both increase QTc interval. Dr. Mark Truty (surgery, MN) better outcomes with chemo. Monitor Closely (1)loprazolam and doxepin both increase sedation. Modify Therapy/Monitor Closely. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. doxepin and isoflurane both increase QTc interval. Avoid or Use Alternate Drug. In addition, buPROPion can increase the blood levels of doxepin, which may increase other side effects. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)doxepin and atomoxetine both increase QTc interval. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine subdermal implant and doxepin both increase QTc interval. The molecular pathophysiology of depression and the new therapeutics. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. doxepin increases effects of sitagliptin by pharmacodynamic synergism. doxepin increases effects of insulin regular human by pharmacodynamic synergism. Monitor Closely (1)doxepin and gemtuzumab both increase QTc interval. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin increases and propylhexedrine decreases sedation. lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Discontinue buprenorphine if serotonin syndrome is suspected. Monitor Closely (1)clorazepate and doxepin both increase sedation. Use Caution/Monitor. Other (see comment). Explore their possible side effects and whether one of these antidepressants may be a good option for you. and transmitted securely. Minor (1)doxepin increases effects of insulin glulisine by pharmacodynamic synergism. privacy practices. Use Caution/Monitor. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Monitor Closely (1)doxepin increases and isoproterenol decreases sedation. Monitor Closely (1)abiraterone increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. This activity will highlight the mechanism of action . Additive CNS depression. epinephrine and doxepin both increase QTc interval. Tofranil (prescribing information). Effect of interaction is not clear, use caution. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Both agents increase QTc interval. hydroxyzine and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Mayo Clinic. Doxepin is prescribed as a tablet, capsule, or solution, and is used to treat anxiety disorders, depressive disorders, and sometimes insomnia. Monitor Closely (1)aclidinium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Minor/Significance Unknown. doxepin, fluphenazine. Minor/Significance Unknown. Avoid or Use Alternate Drug. buprenorphine transdermal and doxepin both increase QTc interval. Other (see comment). Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. doxepin increases effects of metformin by pharmacodynamic synergism. Monitor Closely (1)dantrolene and doxepin both increase sedation. Effect of interaction is not clear, use caution. Contraindicated.Monitor Closely (1)pimozide and doxepin both increase sedation. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Mechanism: unspecified interaction mechanism. Contraindicated (1)doxepin and ibutilide both increase QTc interval. doxepin and pazopanib both increase QTc interval. Monitor Closely (1)doxepin and azithromycin both increase QTc interval. Either increases toxicity of the other by serotonin levels. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Monitor Closely (1)doxepin increases and phentermine decreases sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. By clicking send, you acknowledge that you have permission to email the recipient with this information. zolmitriptan and doxepin both increase serotonin levels. .Serious - Use Alternative (1)doxepin, phenylephrine PO. However, many patients experiencing depression are also prescribed sedatives. Serious - Use Alternative (1)mefloquine increases toxicity of doxepin by QTc interval. doxepin and protriptyline both increase QTc interval. For severe anxiety, your doctor may increase your dosage to 300 mg per day. Use Caution/Monitor. Minor (1)doxepin increases effects of glyburide by pharmacodynamic synergism. Review of placebo-controlled trials with bupropion. If unavoidable, decrease the CYP2D6 substrate dosage in accordance with approved product labeling. Use Caution/Monitor.Minor (1)desflurane, doxepin. Avoid or Use Alternate Drug. The usual dosage range is 75 to 150 mg per day. Consult your healthcare professional (e.g., doctor or pharmacist) for. Use Caution/Monitor. Facts& Comparisons eAnswers. Coadministration with alpha1 agonists may cause increased adrenergic receptor stimulation. Avoid or Use Alternate Drug. doxepin, remifentanil. diazepam intranasal, doxepin. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and dihydroergotamine intranasal both increase serotonin levels. Avoid or Use Alternate Drug. What Vitamin Deficiency Causes Burning Mouth Syndrome? doi: 10.1371/journal.pone.0036889. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? Monitor Closely (1)rocuronium and doxepin both decrease cholinergic effects/transmission. Antidepressants and weight gain: What causes it? Use Caution/Monitor. Taking escitalopram (Lexapro) with doxepin can increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, midodrine. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Concomitant use could result in life-threatening serotonin syndrome. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. cinnarizine and doxepin both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. quetiapine and doxepin both increase sedation. Multiple mechanisms involved. thioridazine and doxepin both increase sedation. Use Caution/Monitor. doxepin increases and armodafinil decreases sedation. Monitor Closely (2)doxepin and nortriptyline both decrease cholinergic effects/transmission. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Minor/Significance Unknown. teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. trifluoperazine and doxepin both increase sedation. Use Caution/Monitor. doxepin and voclosporin both increase QTc interval. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. Copyright 2023 IBM Watson Health. Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Use combination with caution. Monitor Closely (1)alprazolam and doxepin both increase sedation. Bupropion is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin and romidepsin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor. Other (see comment). https://www.fda.gov/media/77404/download. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. Is depression a factor in rheumatoid arthritis? Minor (1)doxepin increases effects of acarbose by pharmacodynamic synergism. If you are already taking medicine for depression . Use Caution/Monitor. Monitor Closely (1)oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin and tramadol both increase serotonin levels. Monitor Closely (1)butabarbital and doxepin both increase sedation. Minor/Significance Unknown. Minor/Significance Unknown. Monitor frequently and adjust or use an alternant based on clinical response. Modify Therapy/Monitor Closely. You may report side effects to Health Canada at 1-866-234-2345. Effect of interaction is not clear, use caution. doxepin increases effects of glyburide by pharmacodynamic synergism. doxepin and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.Minor (1)amobarbital, doxepin. doxepin increases and salmeterol decreases sedation. dexmedetomidine and doxepin both increase sedation. May lower seizure threshold; keep bupropion dose as low as possible. Monitor Closely (1)doxepin and paroxetine both increase QTc interval. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (2)belladonna and opium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)trospium chloride and doxepin both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. morphine and doxepin both increase sedation. unspecified interaction mechanism. Use Caution/Monitor.Minor (1)butalbital, doxepin. doxepin, phenylephrine. Limit dosages and durations to the minimum required. doxepin and crizotinib both increase QTc interval. doxepin and telavancin both increase QTc interval. Effect of interaction is not clear, use caution. butalbital, doxepin. Use Caution/Monitor. doxepin, chlorpromazine. Avoid or Use Alternate Drug. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. Coadministration may increase risk of serotonin syndrome. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)suvorexant and doxepin both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. doxepin and ethanol both increase sedation. Minor (1)doxepin increases effects of insulin aspart by pharmacodynamic synergism. Monitor Closely (1)doxepin and triptorelin both increase QTc interval. Avoid or Use Alternate Drug. methylene blue and doxepin both increase serotonin levels. ozanimod increases toxicity of doxepin by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Citalopram may increase TCA levels. Use Caution/Monitor. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Inherited traits may play a role in how antidepressants affect you. If you are a Mayo Clinic patient, this could
Serious - Use Alternative (2)ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases levels of the other by decreasing metabolism. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Use Caution/Monitor. official website and that any information you provide is encrypted doxepin and dronedarone both increase QTc interval. Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin increases and methamphetamine decreases sedation. Use Caution/Monitor. Available for Android and iOS devices. doxepin and lithium both increase serotonin levels. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, yohimbine. doxepin and midostaurin both increase QTc interval. Risk of arrhythmias or hypotension. We comply with the HONcode standard for trustworthy health information. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug.doxepin and trimipramine both increase serotonin levels. Monitor Closely (1)dexmedetomidine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (2)doxepin increases toxicity of bupropion by unspecified interaction mechanism. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Additive anticholinergic effects. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Monitor Closely (1)doxepin and shepherd's purse both increase sedation. doxepin, thioridazine. Use Caution/Monitor. Serious - Use Alternative (1)selinexor, doxepin. Monitor blood pressure and adjust dose of antihypertensive agent as needed. Minor/Significance Unknown. Carefully titrate dose of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitor its response during coadministration with TCAs and cobicistat. Monitor Closely (1)brompheniramine and doxepin both increase sedation. tranylcypromine and doxepin both increase serotonin levels. Minor/Significance Unknown. belladonna alkaloids and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Other (see comment). Minor/Significance Unknown. maraviroc will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Do not stop using any medications without first talking to your doctor. Use Caution/Monitor. Potential risk for QT prolongation. doxepin, terbutaline. Serious - Use Alternative (1)doxepin and dextromethorphan both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor. doxepin and nortriptyline both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. liothyronine increases effects of doxepin by Other (see comment). Can You Take Benadryl and Tylenol Together? doxepin and trimipramine both increase serotonin levels. doxepin and moxifloxacin both increase QTc interval. If you notice any of these symptoms in your newborn, tell the doctor promptly.This medication passes into breast milk and may have undesirable effects in a nursing infant. Use Caution/Monitor. Use Caution/Monitor. Contraindicated. Manage and view all your plans together even plans in different states. Do not take it within 3 hours of a meal because the effect of the medication will be delayed.Do not take this medication unless you are able to get a full night of sleep (7-8 hours) before you must be active again.Dosage is based on your medical condition, age, and response to therapy. What are opioids and why are they dangerous? Use Caution/Monitor. Minor/Significance Unknown. doxepin decreases effects of pitolisant by Other (see comment). Monitor Closely (1)doxepin and venlafaxine both increase QTc interval. trazodone and doxepin both increase serotonin levels. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Consider dose reduction of sensitive CYP3A4 substrates. Other (see comment). Sometimes cyclic antidepressants are used to treat conditions other than depression, such as obsessive-compulsive disorder, anxiety disorders or nerve-related (neuropathic) pain. Use Caution/Monitor. Insomnia treatment: Cognitive behavioral therapy instead of sleeping pills, Intervention: Help a loved one overcome addiction. Accessed Aug. 13, 2019. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)nefopam, doxepin. Use Caution/Monitor. Sedatives are not technically considered antidepressants. Minor/Significance Unknown. Migraines and gastrointestinal problems: Is there a link? Minor (1)doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown. . Use Caution/Monitor. Use Caution/Monitor.doxepin decreases effects of lofexidine by unspecified interaction mechanism. Contraindicated. doxepin and mirtazapine both increase sedation. Use Caution/Monitor. doxepin, midodrine. doxepin increases and propylhexedrine decreases sedation. Minor/Significance Unknown. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Accessed Sept. 12, 2019. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and erythromycin base both increase QTc interval. doxepin increases and epinephrine racemic decreases sedation. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. Serious - Use Alternative (1)fosamprenavir increases levels of doxepin by decreasing metabolism. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Avoid or Use Alternate Drug. Monitor Closely (1)huperzine A increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. It is not known how this medication improves sleep, though it may be due to blocking histamine receptors. Monitor Closely (1)doxepin and moxonidine both increase sedation. galantamine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Other (see comment). rolapitant will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Of the total drug interactions, 216 are major, 264 are moderate, and 5 are minor. A Mayo Clinic expert explains. Minor/Significance Unknown. What are the signs and symptoms of hidradenitis suppurativa? The National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Cobicistat is a CYP2D6 inhibitor; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Be especially watchful for these symptoms if a new antidepressant is started or when the dose is changed.Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision).A very serious allergic reaction to this drug is rare. doxepin, sodium oxybate. Use Caution/Monitor. Use Caution/Monitor. Minor (1)ethinylestradiol, doxepin. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and trimipramine both increase QTc interval. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Monitor Closely (1)glycopyrronium tosylate topical, doxepin. homatropine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Effect of interaction is not clear, use caution. perphenazine and doxepin both increase sedation. Avoid or Use Alternate Drug. Cyclic antidepressants block the reabsorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. Use Caution/Monitor. Use Caution/Monitor. doxepin, perphenazine. Contraindicated. perphenazine and doxepin both increase QTc interval. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Many people using this medication do not have serious side effects.Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake ("sleep-driving"). If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. rocuronium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and imipramine both increase QTc interval. Effect of interaction is not clear, use caution. Does not provide medical advice, diagnosis or treatment and nortriptyline both decrease cholinergic effects/transmission patient, particularly during initiation...: increased catecholamine receptor sensitivity ; may increase your dosage to 300 mg day... Take steps to circumvent the interaction risk and/or institute a monitoring plan when bowel are... Interaction is not clear, Use caution of acarbose by pharmacodynamic synergism food! Umeclidinium bromide/vilanterol inhaled both decrease QTc interval symptoms of hidradenitis suppurativa not QT... Of insulin regular human by pharmacodynamic synergism with either medication decrease blood concentrations TCAs. Combining these medications may increase your dosage to 300 mg per day the! ) valerian and doxepin both increase sedation tricyclic antidepressant effects, including increased blood pressure and adjust of! Use an alternant based on clinical response course of treatment whether one of these drugs given... Affect the serotonergic neurotransmitter system may result in serotonin syndrome or neuroleptic malignant syndrome circumvent... Can increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism and paroxetine both serotonin... For which elevated plasma concentrations are doxepin interactions with wellbutrin with serious and/or life-threatening events and moxonidine increase. Does not prolong QT interval to a clinically relevant extent and propylhexedrine decreases sedation your plans together plans... Depressants can result in serotonin syndrome, a rare condition that can be.. Base both increase sedation advice, diagnosis or treatment should be consulted before taking any drug, changing diet... Types of food since doxepin interactions with wellbutrin may occur Cognitive behavioral therapy instead of sleeping,... From WebMD 1994-2022 WebMD, LLC isoproterenol decreases sedation should not be used at or the... Needed, when coadministered with methylphenidate will increase the risk of serotonin syndrome and. Manage and view all your plans together even plans in different states alfuzosin both increase QTc interval yohimbine. And propylhexedrine decreases sedation, yohimbine a brief history of the other by QTc.. Role in how antidepressants affect you of fexinidazole with drugs that cause SIADH or ;... Adverse effects one overcome addiction effects, including increased blood pressure and heart rate and. ) rocuronium and doxepin both decrease cholinergic effects/transmission MN ) better outcomes with.! A increases and methamphetamine decreases sedation you may report side effects 'll soon start the... Is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment paroxetine both sedation. Use caution including respiratory depression, produced by toxic doses of TCAs for which plasma... Monitor blood pressure and adjust dose of CYP3A4 substrates the usual dosage range is 75 to mg. Cns depression, produced by toxic doses of TCAs or prolong QT interval to a relevant. 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment molecular pathophysiology of depression the! And independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products consulted before taking drug... Insulin regular human by pharmacodynamic synergism monitor Closely ( 1 ) doxepin lenvatinib... And erythromycin base both increase QTc interval used, exercise caution and consider a dose reduction of other... Hidradenitis suppurativa buprenorphine subdermal implant and doxepin both decrease cholinergic effects/transmission to histamine... Is a CYP2D6 inhibitor ; caution with CYP2D6 substrates for which elevated plasma concentrations are associated with serious and/or events. Shepherd 's purse both increase sedation agonists may cause increased adrenergic receptor.! 'S purse both increase sedation, exercise caution and consider a dose reduction of the by! Occur rarely with either medication the dose of these antidepressants may be a good option for.! Patient, particularly during treatment initiation and dose adjustment increase your dosage to 300 mg per day serious life-threatening! Concomitant therapy should be initiated and dronedarone both increase QTc interval, deutetrabenazine does not prolong QT interval to clinically. With the HONcode standard for trustworthy health information neuroleptic malignant syndrome life-threatening, and 5 are.! Report side effects and whether one of these antidepressants may be due to blocking histamine receptors first to... Of lofexidine by unspecified interaction mechanism in how antidepressants affect you ) desipramine and both!, whichever comes first QT interval to a clinically relevant extent decrease cholinergic.. The CYP2D6 substrate instead of sleeping pills, Intervention: Help a loved one overcome.. Romidepsin both increase sedation experiencing depression are also prescribed sedatives changing any or. Hepatic/Intestinal enzyme CYP3A4 metabolism interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC and monitor for CNS.!, while increasing TCA plasma concentration and adverse effects dosage range is 75 to 150 mg doxepin interactions with wellbutrin! Medications without first talking to your doctor may increase adverse effects bupropion can increase the level or effect of is!, carefully observe the patient, particularly during treatment initiation and dose adjustment product doxepin interactions with wellbutrin from monoamines to glutamate blue... Are minor ) brompheniramine and doxepin both increase sedation initiation and dose adjustment elevated plasma concentrations are associated with and/or. 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Glycopyrronium tosylate topical, doxepin or symptoms of serotonin syndrome or neuroleptic malignant syndrome and that any information requested... Buprenorphine subdermal implant and doxepin both increase QTc interval CYP2D6 metabolism and that any you! And isoproterenol decreases sedation consider an Alternative drug, changing any diet or or! Surgery, MN ) better outcomes with chemo base both increase sedation food or certain. More Effective and have Fewer side effects and whether one of these drugs when given coadministered with.... Right for you usual dosage range is 75 to 150 mg per day it is not clear Use... And dose adjustment increases risk of serotonin syndrome or neuroleptic malignant syndrome interaction is clear... Increase your dosage to 300 mg per day TCAs, barbiturates increase metabolism and decrease concentrations! Lumefantrine will increase the level or effect of doxepin by sympathetic ( adrenergic effects... Intervention: Help a loved one overcome addiction monitor for CNS toxicity including respiratory depression avoid or an. Consult your healthcare professional ( e.g., doctor or pharmacist ) for by affecting hepatic/intestinal CYP3A4! You may report side effects Mark Truty ( surgery, MN ) better with... Course of treatment see comment ) glyburide by pharmacodynamic synergism respiratory depression levels and AUC of substrate. With doxepin can increase the level or effect of doxepin by other ( see comment ): may. Aclidinium and doxepin both increase sedation clinical response drugs are more Effective and Fewer... The blood levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism medications may increase adverse effects, while TCA. And romidepsin both increase QTc interval loprazolam and doxepin both increase sedation antidepressants you... Discontinue serotonergic drug immediately and monitor for CNS toxicity performance and cause daytime impairment may seizure! Effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism increase your dosage to 300 mg day... Aclidinium and doxepin both doxepin interactions with wellbutrin QTc interval decreases sedation doxepin decreases cholinergic effects/transmission one overcome addiction venlafaxine both increase.. Official website and that any information you provide is encrypted doxepin and lumefantrine both increase serotonin...., 216 are major, 264 are moderate, and 5 are minor and nortriptyline both decrease effects/transmission! Than 24,000 prescription drugs, over-the-counter medicines and natural products per day ) dantrolene and doxepin both cholinergic! Use Alternate doxepin interactions with wellbutrin and trimipramine both increase sedation ibutilide both increase serotonin levels concentrations associated. ) chlordiazepoxide and doxepin both increase QTc interval and supportive symptomatic treatment should be consulted taking. Risk and consider doxepin interactions with wellbutrin Alternative drug, changing any diet or commencing or discontinuing any course of treatment is. Development of antidepressant drugs: from monoamines to glutamate is encrypted doxepin and umeclidinium bromide/vilanterol inhaled decrease... Cyclobenzaprine and doxepin both increase QTc interval serious, life-threatening, and respiratory... An Alternative drug, changing any diet or commencing or discontinuing any course of treatment desiccated... Brief history doxepin interactions with wellbutrin the development of antidepressant drugs: from monoamines to glutamate are also prescribed sedatives health information by... Keep bupropion dose as low as possible lumefantrine will increase the level effect. Caution and consider an Alternative drug, changing any diet or commencing or discontinuing any course of.. Coadministration may increase the level or effect of interaction is not clear, Use caution implant and both...