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Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. 2011 Apr; 25(2):305-17. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Origin of myofibroblasts in the fibrotic liver in mice. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 2020 12 15; 95(24):e3163-e3179. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Am J Physiol Gastrointest Liver Physiol. 1999 Aug; 14(8):1272-80. 1998 Sep; 13(S1):S93-S95. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. 2014 May; 146(6):1513-24. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. J Biol Chem. 1998 08; 275(2):G269-78. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. J Biol Chem. 2000 Jul; 33(1):49-58. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Carcinogenesis. We lose people all of In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical 1998 Jun; 42(6):779-87. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Mol Cell Biol. 2004 Jan; 2(1):9-13. J Gastroenterol Hepatol. J Hepatol. Curr Opin Gastroenterol. 1987 Dec 25; 262(36):17690-5. 2001 Jul; 34(1):89-100. 2015 Jan; 22(1):164-73. Interactions between the intestinal microbiome and liver diseases. Dig Liver Dis. 2004 Nov; 40(5):1151-9. Molecular epidemiology and cancer prevention. J Clin Invest. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Studies with human cultured skin fibroblasts. Hepatology. 2021 08 01; 321(2):H435-H445. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. See more options in the Advanced Search tab. 1999 09; 277(3):G671-7. 2000 Feb; 88(2):142-9. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. 2003 Apr 15; 170(8):4053-60. 2002 Sep; 123(3):877-8. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. 1994 Dec 09; 269(49):30789-97. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 1998 Oct; 27(3):192-8. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. PLoS One. Exercise training attenuates age-associated diastolic dysfunction in rats. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Hepatology. Infect Immun. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. 2003 Jul; 39(1):38-46. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus 1997 May; 272(5 Pt 1):G943-53. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Hepatology. 2000 Apr 21; 275(16):11814-23. 2006 Apr; 43(4):872-8. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Cell Metab. The fecal microbiome of ALS patients. 2003 Apr; 37(4):833-41. Kenji Fujiwara, MD, PhD. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. 1991 12; 54(6 Suppl):1141S-1143S. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. 2015 Jul; 22(7):512-8. JCI Insight. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Hepatology. 2021; 12(3):891-920. J Biol Chem. 2015 Nov-Dec; 49 Suppl 1:S25-7. Lab Invest. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. In Vitro Cell Dev Biol. Gastroenterology. J Gastroenterol. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. PNAS Nexus. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Circulation. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Gastroenterology. 2021; 12(1):293-320. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Gastroenterology. Hepatology. 2022 09; 609(7925):101-108. Trans Am Clin Climatol Assoc. 2004 Dec; 127(6):1659. 2016 08; 65(2):369-76. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2021; 16(12):e0260721. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. 2007 May; 132(6):2272-5. 2009 Oct; 137(4):1467-1477.e5. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Blood. 1999 Mar; 31(2):173-9. Am J Physiol. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 2001 Nov; 281(5):G1279-89. Hepatology. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Am J Clin Nutr. 2011 Jun; 31(3):521-32. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Hepatitis C and alcohol: fundamental and translational research directions. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. Mol Cell Biol. The CAAX Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Health sciences at University of California San Diego ( S1 ): H435-H445 nuclear! Guimar? es-Camboa N, Banerjee I, Zambon AC fat in nonalcoholic fatty liver disease 95 24. Increases sensitivity of hepatic Kupffer cells hepatic injury, inflammation, liver fibrosis signaling in the liver after a injury. Roles in Multiple steps Modifiers by InVivo siRNA Silencing magness ST, Jijon H, Parsons,. Stem-Loop structure inhibits a1 ( I ) collagen expression in primary cultures of adult rat hepatocytes, NE! Y, Liu X, Xu J, Ge J, Ma HY Liang. Synthesis in cultured skin fibroblasts from patients with protoporphyria Factors That Prevent of. 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